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Filtered Search Results
Medchemexpress LLC Dihydroethidium | 104821-25-2 | 98.83% | 25 MG
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Dihydroethidium, also known as DHE, is a peroxide indicator that penetrates cell membranes to form a fluorescent protein complex with blue fluorescence. After entering cells, it primarily localizes in the cell membrane, cytoplasm, and nucleus, with the strongest staining effect in the nucleus. It produces inherent blue fluorescence and, upon dehydrogenation, combines with RNA or DNA to produce red fluorescence.
- Peroxide indicator
- Penetrates cell membranes
- Forms a fluorescent protein complex with blue fluorescence
- Primarily localized in cell membrane, cytoplasm, and nucleus, strongest staining in the nucleus
- Produces inherent blue fluorescence (Ex 370 nm, Em 420 nm)
- Combines with RNA or DNA after dehydrogenation to produce red fluorescence (Ex 300 nm, Em 610 nm; 535 nm also usable for excitation)
- Solid form
- Pale purple to light pink color
- For research use only
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Medchemexpress LLC Act-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 10MG
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ACT-1004-1239 is a potent, selective, orally available CXCR7 (ACKR3) antagonist developed as a first-in-class compound. It exhibits low nanomolar potency and has shown immunomodulatory and promyelinating effects in preclinical models and early clinical research.
- Potent CXCR7 antagonism with IC50 3.2 nM.
- Orally bioavailable compound suitable for systemic dosing.
- Demonstrated immunomodulatory and promyelinating activity in vivo.
- High chemical purity and solid, stable formulation for storage.
- Compatible with in vitro and in vivo pharmacology studies.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years).
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Medchemexpress LLC Chelerythrine chloride | 3895-92-9 | 99.1% | 100 MG
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Chelerythrine chloride is a cell-permeable benzophenanthridine alkaloid used as a research reagent to inhibit protein kinase C (PKC) and to probe apoptosis and Bcl-2 family interactions in cell-based and biochemical assays.
- Potent PKC inhibitor (IC50 660 nM).
- Inhibits Bcl-XL-Bak BH3 peptide binding (IC50 ~1.5 μM).
- High reported purity (99.11%).
- Supplied as a solid powder; easily soluble in DMSO (4.35 mg/mL).
- Recommended storage: 4°C sealed; in solution store at -80°C for up to 6 months.
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Medchemexpress LLC Methyl phenyl sulfone | 3112-85-4 | MFCD00014741 | 25g
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Methyl phenyl sulfone is a drug impurity
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TARGETMOL CHEMICALS INC CP-466722 10MG
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Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CP-466722 an effective and reversible ATM inhibitor does not inhibit ATR and PI3K or PIKK family members in cells. purity: 99%
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Medchemexpress LLC Ipragliflozin L-Proline | 951382-34-6 | 99.9% | 519.58 | 200 MG
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Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM, showing little to no potency for SGLT1/3/4/5/6. It is intended for research use only.
- Potently and selectively inhibits human, rat, and mouse SGLT2.
- Exhibits stability against intestinal glucosidases.
- Shows good pharmacokinetic properties following oral dosing.
- Dose-dependently increases urinary glucose excretion.
- Reduces blood glucose and plasma insulin levels.
- Improves glucose intolerance.
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Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.47% | 257.30 | 100 MG
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two distinct ligands connected by a linker
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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TARGETMOL CHEMICALS INC MOZAVAPTAN 50MG
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Also available in 10 mg 100 mg 200 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Mozavaptan (OPC-31260) is a competitive vasopressin receptor antagonist for both V1 and V2 receptors with IC50 of 1.2 uM and 14 nM respectively. purity: 99%
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TARGETMOL CHEMICALS INC Abiraterone 200MG
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Also available in 1 g, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50 4 nM). Purity 99.87%
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Medchemexpress LLC Sulfo-SPDB-DM4 | 1626359-59-8 | 99.9% | 1075.66 g·mol⁻¹ | C46H63ClN4O17S3 | 1 MG
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sulfo-SPDB-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that connects the maytansinoid cytotoxin DM4 to biomolecules via a cleavable sulfo-SPDB disulfide linker, allowing intracellular release of the payload after internalization. Intended for research use only, it is supplied as a high-purity analytical material for conjugation and characterization workflows.
- maytansinoid (DM4) antitubulin payload for potent cytotoxicity.
- cleavable sulfo-SPDB disulfide linker enables controlled intracellular release.
- sulfo modification improves aqueous handling and conjugation efficiency.
- high purity suitable for analytical and development use.
- soluble in DMSO at high concentration for formulation flexibility.
- appropriate for ADC construction, characterization, and analytical standards.
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TARGETMOL CHEMICALS INC Muscone 200MG
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Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
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TARGETMOL CHEMICALS INC Amisulpride 200MG
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Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Amisulpride (DAN 2163) (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (under the brand name Deniban). Amisulpride is a selective dopamine antagonist. Purity 100%
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Apexbio Technology LLC Olmesartan medoxomil 144689-63-4 200mg
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Olmesartan medoxomil (CAS 144689-63-4) is the medoxomil ester prodrug of olmesartan which functions as an orally bioavailable antagonist of the angiotensin II type 1 (AT1) receptor Following gastrointestinal absorption it is rapidly converted to its active metabolite olmesartan resulting in potent AT1 receptor inhibition (IC50 8 nmol/L for olmesartan 33 nmol/L for olmesartan medoxomil) The esterification with medoxomil enhances aqueous solubility Olmesartan medoxomil is widely used in hypertension research enabling evaluation of AT1 receptor blockade on vascular tone blood pressure regulation and renal sodium handling in preclinical and clinical models
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Apexbio Technology LLC Phenanthrene 85-01-8 200mg
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Phenanthrene is a polycyclic aromatic hydrocarbon (PAH) that exerts its biological activity primarily through the induction of cellular inflammatory responses enhancement of reactive oxygen species (ROS) generation and activation of apoptotic signaling pathways Based on these pharmacological properties phenanthrene is utilized in research to study PAH-induced cellular toxicity oxidative stress mechanisms and programmed cell death pathways Additionally it serves as a representative analyte in environmental toxicology investigations to detect quantify and evaluate PAH contamination in water and soil supporting the development of toxicological evaluation models and detection methods
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TARGETMOL CHEMICALS INC Zorifertinib 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor. The IC50 values were 0.2, 0.3 and 0.2 nM for EGFR L858R mutant, TK wild-type, and Exon 19Del enzymes, respectively. Purity 99.36%
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